Pharmaceutical Analysis I (All units)
Pharmaceutics
Unit 1: Notes
A) Introduction to dosage form notes PPT
Unit 2: Notes
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What does the term "posology" primarily deal with?
a) Drug formulation
b) Dosage of medicines
c) Pharmacokinetics
d) Adverse drug reactions
Answer: b) Dosage of medicines -
The dose of a drug depends on which of the following factors?
a) Age of the patient
b) Body weight of the patient
c) Severity of the disease
d) All of the above
Answer: d) All of the above -
Which rule is commonly used to calculate pediatric doses based on age?
a) Fried’s Rule
b) Young’s Rule
c) Clark’s Rule
d) Dilling’s Formula
Answer: b) Young’s Rule -
Clark’s Rule for pediatric dosing is based on:
a) Age
b) Surface area
c) Body weight
d) None of the above
Answer: c) Body weight -
The dose of a drug is generally reduced for elderly patients because:
a) Their body weight is higher
b) They have impaired drug metabolism
c) They require stronger effects
d) None of the above
Answer: b) They have impaired drug metabolism -
Which of the following units is commonly used for calculating drug doses for infants and children?
a) mg/kg of body weight
b) mL/hour
c) mg/m² of body surface area
d) None of the above
Answer: a) mg/kg of body weight -
What does the term "therapeutic dose" mean?
a) The maximum dose a patient can tolerate
b) The dose required to achieve a desired therapeutic effect
c) The dose causing toxic effects
d) The average dose for a population
Answer: b) The dose required to achieve a desired therapeutic effect -
Which formula is used to calculate pediatric dose based on body surface area?
a) Young’s Rule
b) Clark’s Rule
c) Surface Area Method
d) Fried’s Rule
Answer: c) Surface Area Method -
A single dose of a drug given immediately to achieve rapid therapeutic levels is called a:
a) Loading dose
b) Maintenance dose
c) Lethal dose
d) Minimal dose
Answer: a) Loading dose -
What is the primary reason for adjusting drug doses in neonates?
a) Faster drug absorption
b) Immature liver and kidney function
c) Higher body fat percentage
d) Increased metabolic rate
Answer: b) Immature live.
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Which of the following is the most commonly used base for suppositories?
a) Beeswax
b) Cocoa butter
c) Glycerin
d) Lanolin
Answer: b) Cocoa butter -
Suppositories are usually intended for administration via which route?
a) Oral
b) Intravenous
c) Rectal
d) Subcutaneous
Answer: c) Rectal -
What is the key characteristic of an ideal suppository base?
a) Melts at body temperature
b) Highly viscous
c) Absorbed systemically
d) Has a high boiling point
Answer: a) Melts at body temperature -
Which method is commonly used for preparing suppositories?
a) Triturating method
b) Cold compression method
c) Heating and molding method
d) All of the above
Answer: d) All of the above -
The ideal melting point for a suppository base should be:
a) Below 25°C
b) Around 37°C
c) Above 45°C
d) At 100°C
Answer: b) Around 37°C -
Which type of suppository is used for systemic drug delivery?
a) Rectal
b) Vaginal
c) Urethral
d) Nasal
Answer: a) Rectal -
Glycerin-based suppositories are mainly used as:
a) Antibiotics
b) Anti-inflammatory agents
c) Laxatives
d) Antifungal agents
Answer: c) Laxatives -
What is the displacement value in suppositories?
a) The weight of suppository
b) The amount of base displaced by a drug
c) The density of the suppository
d) The volume of the drug content
Answer: b) The amount of base displaced by a drug -
Which of the following bases is water-soluble?
a) Cocoa butter
b) Witepsol
c) Polyethylene glycol (PEG)
d) Lanolin
Answer: c) Polyethylene glycol (PEG) -
Which of the following suppositories is not solid at room temperature?
a) Cocoa butter suppository
b) PEG suppository
c) Gelatin-glycerin suppository
d) None of the above
Answer: c) Gelatin-glycerin suppository -
What is the main advantage of PEG as a suppository base?
a) It is non-irritating
b) It provides quick drug release
c) It does not melt but dissolves slowly
d) It has a high viscosity
Answer: c) It does not melt but dissolves slowly -
What is the purpose of using surfactants in suppository formulations?
a) To provide emulsification
b) To enhance solubility of drugs
c) To ensure proper mixing
d) All of the above
Answer: d) All of the above
Ointments
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Ointments are primarily intended for which type of application?
a) Parenteral
b) Topical
c) Oral
d) Rectal
Answer: b) Topical -
The main characteristic of an ointment base is:
a) Spreadability on the skin
b) High boiling point
c) High solubility in water
d) None of the above
Answer: a) Spreadability on the skin -
Which of the following is an example of an oleaginous ointment base?
a) PEG
b) Petrolatum
c) Lanolin
d) Glycerin
Answer: b) Petrolatum -
Which ointment base has the property of water absorption?
a) Hydrocarbon base
b) Anhydrous lanolin
c) Oleaginous base
d) Silicones
Answer: b) Anhydrous lanolin -
What is the role of humectants in ointment formulations?
a) To retain moisture
b) To provide viscosity
c) To act as preservatives
d) To enhance solubility
Answer: a) To retain moisture -
What is the main disadvantage of hydrocarbon bases?
a) Non-greasy nature
b) Poor water washability
c) Poor stability
d) Expensive
Answer: b) Poor water washability -
Which of the following is a water-removable base?
a) Beeswax
b) Petrolatum
c) Vanishing cream
d) Paraffin
Answer: c) Vanishing cream -
Fusion method in ointment preparation involves:
a) Cold mixing of ingredients
b) Heating and melting ingredients together
c) Filtration of ointment base
d) Triturating the components
Answer: b) Heating and melting ingredients together -
What type of emulsions are ointments usually formulated as?
a) W/O or O/W
b) Only W/O
c) Only O/W
d) None of the above
Answer: a) W/O or O/W -
Which of the following ointment bases can absorb water?
a) Petrolatum
b) Anhydrous lanolin
c) Mineral oil
d) Paraffin wax
Answer: b) Anhydrous lanolin -
What is the role of preservatives in ointments?
a) To prevent microbial contamination
b) To provide better fragrance
c) To enhance drug solubility
d) To improve spreadability
Answer: a) To prevent microbial contamination -
Which of the following ointments has a dual action of lubrication and hydration?
a) Hydrocarbon-based ointments
b) Absorption-based ointments
c) Water-removable ointments
d) Water-soluble ointments
Answer: b) Absorption-based ointme.
1. Which of the following is NOT a semi-solid dosage form?
A. Ointment
B. Cream
C. Suppository
D. Tablet
Answer: D. Tablet
2. What is the primary base used in ointments?
A. Hydroalcoholic base
B. Oleaginous base
C. Polysaccharide base
D. Gelatin base
Answer: B. Oleaginous base
3. Which type of ointment base is water-removable and provides a cooling effect?
A. Hydrocarbon base
B. Absorption base
C. Water-removable base
D. Water-soluble base
Answer: C. Water-removable base
4. What is the primary advantage of semi-solid dosage forms over oral dosage forms?
A. Increased systemic absorption
B. Localized drug delivery
C. Faster onset of action
D. None of the above
Answer: B. Localized drug delivery
5. Which of the following bases is used in the preparation of water-soluble ointments?
A. Paraffin
B. Lanolin
C. Polyethylene glycol (PEG)
D. Beeswax
Answer: C. Polyethylene glycol (PEG)
6. Gels are semi-solid preparations that use which of the following as a gelling agent?
A. Mineral oil
B. Carbomers
C. Lanolin
D. Cocoa butter
Answer: B. Carbomers
7. Which of the following methods is used for preparing ointments?
A. Infusion
B. Levigation
C. Granulation
D. Compression
Answer: B. Levigation
8. Which of the following statements is true about creams?
A. They are always hydrophobic.
B. They can be either oil-in-water (O/W) or water-in-oil (W/O) emulsions.
C. They are solid dosage forms.
D. They are used only for systemic drug delivery.
Answer: B. They can be either oil-in-water (O/W) or water-in-oil (W/O) emulsions.
9. Which type of semi-solid dosage form is designed for rectal or vaginal use?
A. Ointment
B. Suppository
C. Cream
D. Paste
Answer: B. Suppository
10. What is the function of humectants in semi-solid dosage forms?
A. To provide fragrance
B. To retain moisture
C. To increase viscosity
D. To act as a preservative
Answer: B. To retain moisture
11. Which of the following is a property of pastes?
A. High lipid content
B. Low drug concentration
C. Better adherence to the skin
D. Used only for oral application
Answer: C. Better adherence to the skin
12. What is the ideal particle size of a drug for use in semi-solid dosage forms to ensure smooth application?
A. 1–5 microns
B. 50–100 microns
C. 10–20 microns
D. 200–300 microns
Answer: A. 1–5 microns
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