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The oxford university vaccine's the one it's
working on with Astrazeneca it is now admitting to making a key mistake during
its vaccine testing and that is this morning raising major questions about the
data about effectiveness.
We have to look at what happened during the trials.
There were two groups of volunteers who took part, however, the first group
received two identical doses of the vaccine but because of a manufacturing
error the second group received half a dose and then a full dose of the vaccine.
Now in the group that got the two full doses, the vaccine appeared to be 62
percent effective while in the low dose group it appeared to be 90 effective
and that was a big surprise but AstraZeneca did the sums. It did the math and
said overall look our vaccine is around 70 percent effective in total but the way those results have been collated has raised some eyebrows heather. One of the
issues are the different sizes of the two groups; the low dose group was much
smaller than the other group and some experts say that makes it difficult to
know if the vaccine's 90 effectiveness in the low dose group is real or merely a
statistical quirk.
Another issue heather consider concerns the
different ages of the participants. Now none in the low dose group were over
the age of 55 years old and younger people tend to mount stronger immune
responses. Some say that could have made the vaccine look more effective in the
low dose group; so we have two different groups of participants here heather
which has received different doses of this vaccine and as a result, some are
struggling to understand how AstraZeneca arrived at that overall figure of 70
effectiveness. Heather certainly raising questions the world is watching this and
the other vaccine candidates' Dominic but we heard for example from Oxford University
say they hope to have three billion doses ready by the end of next year. Canada
is untapped by 20 million doses of this particular vaccine so with all of this
up in the air. Now, what does this mean for the vaccine? Well first off I think
it's important to say that Zenica has defended um the trial saying that it was conducted
to the highest standards. It also says that more data will continue to
accumulate and that additional analysis will be conducted and those results
will then be peer-reviewed hopefully in the next few weeks and they will then
be provided to UK regulators, who will make a final decision on whether or not
to green light. This particular vaccine so more data is in the pipeline heather
it looks like we don't still yet have a complete picture about this vaccine and
that possibly explains some of the current confusion surrounding it heather Dominic
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