Give a ketogenic diet and help with
a coronavirus.
I'm
Dr. Abhinandan, the dietician and Researcher back here to give you updates on
Coronavirus. In this crazy, unprecedented time when the whole world is really
trying to find some sliver of hope of how to prevent or treat a novel infection
a lot of attention has turned to nutrition. I recently wrote a post that we
covered here at www.abhiguru.com and post
on diet. We focus on shreds of evidence, say about boosting your immune system, and part
of that I address nutrition. I've been getting more questions specifically
about what does a ketogenic diet do in? Is there something beneficial about it
to either prevent infection with the coronavirus or prevent complications?
WHAT IS KETOGENIC DIET?
In
order to explain how the ketogenic diet works, I must first explain the basic
workings of the body's metabolism. Your body has two opposing biochemical pathways
promoted by the peptide hormones insulin and glucagon. Think of them as the yin
and yang of your metabolism, where the goal is to balance your blood glucose
levels to maintain the availability of energy for your body's cells. Insulins' job
is to lower blood sugar levels. It does this by promoting the uptake of glucose
into cells. Once glucose is absorbed into cells, it can undergo glycogenesis or
lipogenesis. Glycogenesis is the process by which glucose absorbed by the cells is
converted to the polysaccharide glycogen and lipogenesis is the process by
which glucose is converted to triglycerides. In other words, fat glycogenesis occurs
in skeletal muscles. Lipogenesis occurs in fat cells and both of these processes
occur in the liver. Glucagon's job is the opposite as it raises blood sugar
levels by promoting glycogenolysis and gluconeogenesis. In glucose analysis, glucagon
binds receptors in the liver. The liver cells then convert glycogen to glucose
and release it into the blood. An average person's glycogen stores can last
about 12 to 14 hours or 2 hours, of moderate exercise. This is maintained via the
ingestion of about 250 to 400 grams of carbs daily. Glycogen stores run out during
prolonged exercise, hence the feeling that you hit a wall and can't keep going
it can also be depleted during fasting. Low carb diets or with untreated type 1
diabetes gluconeogenesis is the term for the metabolic pathway in which glucose
is generated from non-carb sources like glycerol which are components of fat or
from glucose.
FACT
No
any study about nutrition in this novel coronavirus outbreak is designed or
talked about it. We have no idea. But there are plenty of studies out there
that we can try and pull from to talk about it. Well, how does this affect our
immune system and how might it affect certain infections. Interestingly, as I
was looking into this I found a study back from the 1930s where investigators looked
at the ketogenic diet for treating urinary tract infections. So this isn't the
first time this question came up they thought it was probably helpful as it
turned the urine acidic and made it with the acetone coming out. That's a
completely different story, completely different infection, but very interesting
this isn't the first time it came up now. What we eat clearly can affect our
immune system? There's no question about that so it makes sense that there
might be a relationship. Now, one study that's been getting a lot of attention
is a recent study in mice. Half of them were inoculated with influence simple
diet. Later half of them got a ketogenic version, and those who have the ketogenic
version had improved function of a T-cell, which is a sort of an immune cell in
their lungs which reduces their manifestation of the infection of influenza. Now, this is an interesting study because it shows the importance of how to measure
immune function. The study measured T-cell functioning which is important. It
also measured whether or not they actually got the infection, that's what we
care about. Because there are a lot of studies that will measure you know a
specific immune function, but not actually measure if you get the infection or
not or have a complication from the infection. This one did, so that's pretty
reassuring, but of course it was in mice, so ketosis and mice may be the different things
you ptosis. In humans an immune system and immune function, especially talking
about lung function responding to viruses all are very different from mice to
humans. Although that does have some encouraging information, it's still a big
jump to say it's going to be the same in humans. Now there's also evidence that
ketones themselves can inhibit what we call them as inflammatory mediators. It is felt to bean an inflammatory process in
the body and part of the complication. Once you get a coronavirus infection you
may get an extreme inflammatory response and that's where the RDS the lung disease
can come from a heightened. The inflammatory response was so inhibiting that it could
potentially be beneficial. No evidence to say that it clearly is but theoretically
connecting the dots.
Evidence
The study, published in Science Immunology, claimed that Keto-diet enhances mucus
production in the body and fights the flu-like symptoms. The study says that long
term use of Keto diet boost body immune system to fight coronavirus. The mice
studies also proven that this diet block the formation of inflammasomes, which
is against COVID-19 development inside the body.
Moral of story
Any
diet which act as immunity-boosting foods should be included to fight against
all viral diseases (particularly rich in vitamin C, zinc) and the ones which
keep you healthy and happy.
If
stomach happy ……….. you are also happy.
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